Small colony variant-producing S aureus prosthesis joint infection highlighted by sonication and treated with prolonged high doses of daptomycin.
نویسندگان
چکیده
Laboratoire de Bactériologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France Université Claude Bernard Lyon 1, Lyon, France Service de Chirurgie Orthopédique, Centre Albert Trillat, Hôpital de la CroixRousse, Hospices Civils de Lyon, Lyon, France Centre Interrégional de Référence Rhône-Alpes Auvergne des Infections Ostéoarticulaires complexes, Lyon, France Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, ENS de lyon, UCBL1, Lyon, France Centre National de Référence des Staphylocoques, Lyon, France Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
منابع مشابه
Adjunctive rifampin is crucial to optimizing daptomycin efficacy against rabbit prosthetic joint infection due to methicillin-resistant Staphylococcus aureus.
Daptomycin is an attractive option for treating prosthetic joint infection, but the 6-mg/kg of body weight/day dose was linked to clinical failure and emergence of resistance. Using a methicillin-resistant Staphylococcus aureus (MRSA) knee prosthesis infection in rabbits, we studied the efficacies of high-dose daptomycin (22 mg/kg given intravenously [i.v.] once daily [o.d.]; equivalent to 8 mg...
متن کاملSonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty
BACKGROUND Culturing of the sonication fluid of removed implants has proven to be more sensitive than conventional periprosthetic tissue culture for the microbiological diagnosis of prosthetic joint infection. Since bacteria surviving on antibiotic-loaded cement spacers used in a two-stage exchange protocol for infected arthroplasties may cause the persistence of infection, in this study we ask...
متن کاملEvaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection
BACKGROUND Daptomycin is a novel cyclic lipopeptide whose bactericidal activity is not affected by current antibiotic resistance mechanisms displayed by S. aureus clinical isolates. This study reports the therapeutic activity of high-dose daptomycin compared to standard regimens of oxacillin and vancomycin in a difficult-to-treat, rat tissue cage model of experimental therapy of chronic S. aure...
متن کاملDaptomycin pharmacodynamics against Staphylococcus aureus hemB mutants displaying the small colony variant phenotype.
OBJECTIVES Staphylococcus aureus small colony variants (SCVs) are slow-growing morphological variants associated with persistent infections. While vancomycin activity has been shown to be attenuated against SCVs of S. aureus, few data exist regarding daptomycin. The objective was to evaluate the pharmacodynamics of daptomycin against defined S. aureus mutants displaying the SCV phenotype. MET...
متن کاملPeriprosthetic Joint Infections
Implantation of joint prostheses is becoming increasingly common, especially for the hip and knee. Infection is considered to be the most devastating of prosthesis-related complications, leading to prolonged hospitalization, repeated surgical intervention, and even definitive loss of the implant. The main risk factors to periprosthetic joint infections (PJIs) are advanced age, malnutrition, obe...
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عنوان ژورنال:
- BMJ case reports
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013